Preparation and immunogenic properties of a recombinant West Nile subunit vaccine
نویسندگان
چکیده
منابع مشابه
Evaluation of the efficacy of a recombinant subunit West Nile vaccine in Syrian golden hamsters.
The efficacy of a recombinant subunit West Nile (WN) vaccine candidate was determined in a hamster model of encephalitis. Animals included young, aged, and immunocompromised animals in an effort to simulate key groups at risk of WN virus-induced disease. Groups of aged (12 month old), weanling, and adult hamsters rendered leukopenic after immunization were immunized subcutaneously with a WN vir...
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West Nile (WN) virus is an important cause of febrile exanthem and encephalitis. Since it invaded the U.S. in 1999, >19,000 human cases have been reported. The threat of continued epidemics has spurred efforts to develop vaccines. ChimeriVax-WN02 is a live, attenuated recombinant vaccine constructed from an infectious clone of yellow fever (YF) 17D virus in which the premembrane and envelope ge...
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Haemagglutinin and neuraminidase have clearly been shown to be responsible for the stimulation of immunity against influenza. In the approach described, these two immunogens are selectively solubilized, leaving an intact subviral particle which contains lipid and non-protective components. The methods used can readily be adapted to large scale production. The immunogenicity of such antigen-prep...
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Brucella bacterium causes Brucellosis, an infectious disease spreading from animals to human. Brucella lumazine synthase (BLS) is a highly immunogenic protein with adjuvant properties, which has been introduced as an effective protein carrier for vaccine development. This protein also plays a significant role in inducing immune system. This study aimed to clone, express, and purify the BLS gene...
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The West Nile virus (WNC) first appeared in North America in 1999. The North American lineages of WNV were characterized by the presence of neuroinvasive and neurovirulent strains causing disease and death in humans, birds and horses. The 2012 WNV season in the United States saw a massive spike in the number of neuroinvasive cases and deaths similar to what was seen in the 2002-2003 season, acc...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2007
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2006.08.018